Infertility affects 15% of couples and affects both males and females equally.
There are various causes of infertility, which can be classified into a few broad categories and often occur simultaneously, and can be identified through genetic tests.
In some cases, there is not just one gene associated with infertility, but several genetic tests are needed to determine the cause.
THERE CAN BE DIFFERENT GENES INVOLVED IN INFERTILITY.
For this reason, Eurofins Genoma offers different genetic tests, from the most classic to the most innovative.
All the answers you need, in a single solution designed for you.
Our fertility tests:
Woman
- Fertiscan®
- chromosome test
- cystic fibrosis test
- X-fragile test
- thrombophilia test
Man
- Fertiscan®
- chromosome test
- cystic fibrosis test
- Y chromosome microdeletion test
Fertiscan® is a comprehensive and innovative genetic test to identify the causes of female and male infertility in couples who have difficulty having children.
SIMPLE. RELIABLE. COMPLETE.
Fertiscan
FEMALE
INFERTILITY PANEL
2 LINES OF INVESTIGATION
Fertiscan
MALE
INFERTILITY PANEL
The Fertiscan® test is performed with a simple blood sample.
2 LINES OF INVESTIGATION
Fertiscan
FEMALE
INFERTILITY PANEL
Fertiscan
MALE
INFERTILITY PANEL
The Fertiscan® test is performed with a simple blood sample.
Fertiscan Woman is available in two levels of investigation: a more complete analysis, which simultaneously analyzes 70 genes for the study of the main genetic causes associated with infertility and recurrent abortions; a more targeted analysis for investigating specific genetic disorders.
Test variants:
Fertiscan Global Male Infertility Panel is a test that simultaneously analyzes 50 genes for the study of the main genetic causes of male infertility.
Variants of the test:
TEST characteristics
Simple
A blood sample is analyzed
Reliable
Reliability > 99%
Complete
In-depth investigation for the identification of genetic causes of infertility
Advanced
Advanced technologies and sophisticated analysis methods
Who we recommend
Fertiscan® to
Couples with recurring abortion conditions
Couples who have tried assisted fertilization multiple times
Couples who would like to try assisted fertilization
Couples with hereditary infertility conditions
Couples with reproductive difficulties
The chromosome test, or chromosomal analysis, is an exam that allows the study of the number and/or structure of an individual’s chromosomes. The purpose of this test is to identify any anomalies responsible for different diseases.
Chromosomal alterations in healthy individuals can cause infertility, reduced fertility, multiple abortions, birth of children with pathologies.
The chromosome test is performed with a simple blood sample.
The chromosome test is an exam that we recommend to anyone who has difficulties having children: even clinically healthy subjects.
Chromosomal anomalies are in fact the main cause of male infertility and female infertility.
Why is it important?
Alterations of the number or structure of sexual chromosomes (chromosome X, chromosome Y) can lead to sexual development pathologies that cause infertility.
These alterations, if present in an individual, can:
- directly interfere with their reproductive abilities;
- cause the formation of gametes with difficulty fertilizing (if sperm) or being fertilized (if eggs);
- in case of successful fertilization, neonates with multiple anomalies may be born.
Any chromosomal anomaly can be highlighted through the chromosomal analysis.
Cystic fibrosis is the most common serious genetic disease in the world.
It is known for the frequent lung infections it causes and the chronic respiratory problems associated with it. However, it affects organs and tissues throughout the body, including the urinary system.
The genetic test for cystic fibrosis allows to discover if there is an error on a certain gene: if the gene contains the anomaly, it can cause the disease.
Relatives without the disease may also carry the gene and pass it on to future generations.
The cystic fibrosis test is performed with a simple blood sample.
Most men with cystic fibrosis (between 97% and 98%) are infertile.
Cystic fibrosis does not cause infertility in women to the same extent as in men. However, it can affect the female reproductive system and make conception more difficult.
The X-fragile syndrome is a genetic disease that causes autism and mental retardation and is caused by a genetic anomaly of a gene located on the X chromosome.
To discover if you are carriers of the X-fragile syndrome or conditions related to anomalies of the same gene and to determine the risk of generating offspring with X-fragile syndrome, the X-fragile test is required.
In women, the X chromosome anomaly causes in 20% of cases an insufficiency of the function of the ovaries.
Among its consequences are forms of infertility or “subfertility,” irregular or absent menstrual cycles, early menopause (before age 40) and hormonal anomalies.
In cases of poor ovarian function, it is important to do the X-fragile test not only to discover if you are carriers of the condition, but also to establish if there is a high risk of having a child with the X-fragile syndrome, the most common cause of mental retardation.
The result is also useful in determining if there are other women in the family at risk of transmitting the disease.
Thrombophilia is the excessive increase in the risk of blood clots, which obstruct or prevent normal blood circulation.
The Thrombophilia Test allows you to evaluate genetic predisposition to the condition and is essential to ensure that thrombophilia is not a cause of infertility or to verify that it is not an obstacle to implantation.
The thrombophilia test is performed with a simple blood sample.
Today thrombophilia is considered a possible cause of female infertility and is taken into consideration when other causes are excluded or after repeated failures of medically assisted fertilization.
Why is it important to do the thrombophilia test?
The presence of a thrombophilic condition can represent a possible obstacle to a possible implantation of the embryo in the uterus.
The formation of clots puts pregnancy at risk. Blood tends to coagulate more to reduce the possibility of bleeding during childbirth, but this increases the risk of thrombophilia.
Thrombophilia is the cause of 40% of recurrent abortions. Other related risks are fetal intrauterine death, late or premature detachment of the placenta and Fetal underdevelopment.
Microdeletion refers to the loss of a piece of the chromosome and the genes contained within. The Y chromosome is the chromosome that is passed from the father to the male child and contains some genes responsible for spermatogenesis (formation of sperm).
Y chromosome microdeletions are one of the most common causes of male infertility.
- They can be inherited
- They can arise for the first time in a subject
The Y chromosome microdeletion test is performed with a simple blood sample.
The Y chromosome microdeletion test can evaluate if the loss of small portions of the Y chromosome is causing infertility.
Why is the Y chromosome microdeletion test important?
Currently, with the development of molecular biology techniques, it is possible to demonstrate the presence of Y chromosome microdeletions that are so small that they cannot be detected by a classic karyotype examination.
It is very important especially for those couples who are facing assisted procreation, to know with greater precision the possibility of transmitting the same infertility problem to a child.
Knowing the type of Y deletion can help the doctor in determining the best type of assisted fertilization treatment for the infertile couple.